Are we on the verge of a technological paradise? If so, I recommend loading up on the tech and biotech index funds. But I guess even if you are short these indexes, you will still be happy in paradise. So maybe it is better to hedge your bets and go short these indexes. From wireheading.com:

In the 1950s, James Olds and his colleagues invented a procedure known as intracranial self-stimulation. By implanting a permanent thin wire-electrode in a rat's brain, the captive rodent was given the ability to self-administer a small electric shock. The current used is typically less than 0.0005 amperes. The pulse lasts for less than a second: the rodent wirehead must press the lever again to get another hit. Different placements of the electrode elicit different intensities of response. Rates of up to 10,000 bar-presses an hour may be recorded - but only for pulses delivered to the most rewarding brain-areas. An animal will self-stimulate for a whole day and night without rest, and cross a powerfully electrified grid, to gain access to the lever when its reward-centres are wired up.